免疫原
Synthesized peptide derived from human KY AA range: 510-560
特异性
This antibody detects endogenous levels of KY at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.88% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Kyphoscoliosis peptidase (EC 3.4.-.-)
背景
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011],
功能
function:Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC.,similarity:Belongs to the transglutaminase-like superfamily.,subunit:Interacts with FLNC.,
