基因名称(Gene Name)
CRELD2 UNQ185/PRO211
免疫原
Synthesized peptide derived from human CREL2 AA range: 257-307
特异性
This antibody detects endogenous levels of CREL2 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.32% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Cysteine-rich with EGF-like domain protein 2
背景
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008],
功能
developmental stage:Expressed in all fetal tissues tested.,function:May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.,similarity:Belongs to the CRELD family.,similarity:Contains 2 EGF-like domains.,similarity:Contains 2 FU (furin-like) repeats.,subunit:May interact with CHRNA4.,tissue specificity:Ubiquitously expressed.,
