免疫原
Synthesized peptide derived from human CE060 AA range: 25-75
特异性
This antibody detects endogenous levels of CE060 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.31% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Putative uncharacterized protein C5orf60
背景
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009],
功能
function:Not known; does not seem to have protease activity as it has lost the active site residues.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 C2 domain.,similarity:Contains 1 calpain catalytic domain.,tissue specificity:Expressed only in placenta.,
