基因名称(Gene Name)
SEPT4 ARTS PNUTL2 SEP4 hucep-7
蛋白名称
Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7)
免疫原
Synthesized peptide derived from part region of human protein
特异性
SEPT4 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
septin 4(SEPT4) Homo sapiens This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010],
功能
function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subcellular location:Only observed in tumor tissue cells.,subunit:May assemble into a multicomponent structure.,tissue specificity:Expressed ubiquitously in adult and fetal tissues with particularly high expression in adult heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancer and malignant melanoma samples.,
