基因名称(Gene Name)
DIO2 ITDI2 TXDI2
蛋白名称
Type II iodothyronine deiodinase (EC 1.97.1.10) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase)
免疫原
Synthesized peptide derived from part region of human protein
特异性
IOD2 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
deiodinase, iodothyronine type II(DIO2) Homo sapiens The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may
功能
catalytic activity:3,5,3'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH(2).,function:Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.,function:Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).,similarity:Belongs to the iodothyronine deiodinase family.,tissue specificity:Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain.,
