基因名称(Gene Name)
BRD2 KIAA9001 RING3
蛋白名称
Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein)
免疫原
Synthesized peptide derived from part region of human protein AA range: 300-350
特异性
BRD2 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010],
功能
domain:One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'.,function:May play a role in spermatogenesis or folliculogenesis.,similarity:Contains 1 ET domain.,similarity:Contains 2 bromo domains.,subunit:Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13'.,
