基因名称(Gene Name)
ITSN2 KIAA1256 SH3D1B SWAP
蛋白名称
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
免疫原
Synthesized peptide derived from part region of human protein AA range: 1125-1175
特异性
ITSN2 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. [provided by RefSeq, Jul 2008],
功能
alternative products:Additional isoforms seem to exist,function:Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles.,miscellaneous:Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.,similarity:Contains 1 C2 domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 2 EF-hand domains.,similarity:Contains 2 EH domains.,similarity:Contains 5 SH3 domains.,subunit:Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process.,tissue specificity:Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.,
