基因名称(Gene Name)
GPR78 UNQ5925/PRO19818
蛋白名称
G-protein coupled receptor 78
免疫原
Synthesized peptide derived from human protein . at AA range: 290-370
特异性
GPR78 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)
背景
The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011],
功能
function:Orphan receptor.,induction:Expression increased in fibroblasts or HeLa cells following UV-A irradiation, exposure to DNA-alkylating agents, or endoplasmic reticulum (ER) stress caused by osmotic shock or the glycosylation inhibitor tunicamycin.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in pituitary and placenta. No expression detected in brain, skeletal muscle, lung, heart, liver, pancreas, or kidney.,
