基因名称(Gene Name)
DEFA6 DEF6
蛋白名称
Defensin-6 (Defensin, alpha 6)
免疫原
Synthesized peptide derived from human protein . at AA range: 51-100
特异性
DEF6 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
Cathepsin O (EC 3.4.22.42)
背景
defensin alpha 6(DEFA6) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014],
功能
function:Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.,similarity:Belongs to the alpha-defensin family.,subunit:Homodimer.,tissue specificity:Paneth cells of the small intestine.,
