基因名称(Gene Name)
ID3 1R21 BHLHB25 HEIR1
蛋白名称
DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3)
免疫原
Synthesized peptide derived from human protein . at AA range: 68-117
特异性
ID3 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
PPIA; CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A
背景
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011],
功能
function:ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors.,induction:By phorbol 12-myristate 13-acetate (PMA).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with COPS5 and COPS7A (By similarity). Homodimer, and heterodimer with other HLH proteins.,tissue specificity:Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.,
