基因名称(Gene Name)
B2M CDABP0092 HDCMA22P
蛋白名称
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
B2MG Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; Alteplase; Reteplase
背景
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014],
功能
disease:Defects in B2M are the cause of hypercatabolic hypoproteinemia [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.,function:Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.,online information:Beta-2-microglobulin entry,PTM:Glycation of Ile-21 is observed in long-term hemodialysis patients.,similarity:Belongs to the beta-2-microglobulin family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,
