基因名称(Gene Name)
PEAR1 MEGF12
蛋白名称
Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)
免疫原
Synthesized peptide derived from human protein . at AA range: 910-990
特异性
PEAR1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
RPS13; 40S ribosomal protein S13
背景
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008],
功能
function:When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.,PTM:Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.,similarity:Belongs to the MEGF family.,similarity:Contains 1 EMI domain.,similarity:Contains 9 EGF-like domains.,subcellular location:Detected on the cell surface in resting platelets.,subunit:Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.,tissue specificity:Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas
