基因名称(Gene Name)
TNFRSF19 TAJ TROY UNQ1888/PRO4333
蛋白名称
Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)
免疫原
Synthesized peptide derived from human protein . at AA range: 20-100
特异性
TNR19 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is caMABle of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],
功能
function:Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.,tissue specificity:Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.,
