基因名称(Gene Name)
RAP1B OK/SW-cl.11
蛋白名称
Ras-related protein Rap-1b (GTP-binding protein smg p21B)
免疫原
Synthesized peptide derived from human protein . at AA range: 110-190
特异性
RAP1B Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011],
功能
enzyme regulation:Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:May shuttle between plasma membrane and cytosol.,subunit:Interacts with SGSM1, SGSM2 and SGSM3.,
