基因名称(Gene Name)
ANTXR1 ATR TEM8
蛋白名称
Anthrax toxin receptor 1 (Tumor endothelial marker 8)
免疫原
Synthesized peptide derived from part region of human protein
特异性
ANTR1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008],
功能
alternative products:Experimental confirmation may be lacking for some isoforms,domain:Binding to PA seems to be effected through the VWA domain.,function:Cellular role is not yet known.,similarity:Belongs to the ATR family.,similarity:Contains 1 VWFA domain.,subunit:Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.,tissue specificity:Highly expressed in tumor endothelial cells but not in normal endothelial cells.,
