基因名称(Gene Name)
GPNMB HGFIN NMB UNQ1725/PRO9925
蛋白名称
Transmembrane glycoprotein NMB (Transmembrane glycoprotein HGFIN)
免疫原
Synthesized peptide derived from part region of human protein
特异性
GPNMB Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
glycoprotein nmb(GPNMB) Homo sapiens The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
developmental stage:Expression in poorly metastatic melanoma cell lines; no expression in highly metastatic melanoma cell lines.,function:Could be a melanogenic enzyme.,similarity:Belongs to the Pmel-17/NMB family.,similarity:Contains 1 PKD domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:Not restricted to the melanocytic lineage.,
