基因名称(Gene Name)
CDKN2AIP CARF
蛋白名称
CDKN2A-interacting protein (Collaborator of ARF)
免疫原
Synthesized peptide derived from part region of human protein
特异性
CARF Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
功能
function:Activates TP53/p53 by CDKN2A-dependent and CDKN2A-independent pathways.,PTM:May be ubiquitinated.,similarity:Belongs to the CARF family.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,subunit:Interacts with CDKN2A/p14ARF, TP53/p53 and MDM2.,tissue specificity:Ubiquitously expressed.,
