基因名称(Gene Name)
CREG1 CREG UNQ727/PRO1409
蛋白名称
Protein CREG1 (Cellular repressor of E1A-stimulated genes 1)
免疫原
Synthesized peptide derived from part region of human protein
特异性
CREG1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008],
功能
function:May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.,PTM:N-glycosylated.,similarity:Belongs to the CREG family.,subunit:Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.,
