基因名称(Gene Name)
CXCL17 VCC1 UNQ473/PRO842
蛋白名称
VEGF co-regulated chemokine 1 (C-X-C motif chemokine 17) (Dendritic cell and monocyte chemokine-like protein) (DMC)
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-50
特异性
VCC1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
C-X-C motif chemokine ligand 17(CXCL17) Homo sapiens The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015],
功能
developmental stage:Detected in fetal lung.,function:Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.,induction:Found to be up-regulated in duodenal mucosa during acute cholera.,online information:CXCL17 entry,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,tissue specificity:Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.,
