蛋白名称
UV radiation resistance-associated gene protein (p63)
免疫原
Synthesized peptide derived from part region of human protein. AA range 655-675
特异性
UVRAG Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008],
功能
disease:Disrupted by a Inv(11)(q13.5;q25) inversion in a patient with heterotaxy (left-right axis malformation).,similarity:Contains 1 C2 domain.,tissue specificity:Highly expressed in brain, lung, kidney and liver.,
