基因名称(Gene Name)
AGFG1 HRB RAB RIP
蛋白名称
Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein)
免疫原
Synthesized peptide derived from part region of human protein
特异性
AGFG1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
ArfGAP with FG repeats 1(AGFG1) Homo sapiens The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],
功能
domain:Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev.,function:Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.,PTM:O-glycosylated.,similarity:Contains 1 Arf-GAP domain.,subunit:Interacts with EPS15R and EPS15.,tissue specificity:Ubiquitously expressed.,
