基因名称(Gene Name)
ATRN KIAA0548 MGCA
蛋白名称
Attractin (DPPT-L) (Mahogany homolog)
免疫原
Synthesized peptide derived from part region of human protein
特异性
ATRN Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
attractin(ATRN) Homo sapiens This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, Apr 2016],
功能
function:Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system.,induction:Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.,online information:Attractin-2,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 CUB domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 2 laminin EGF-like domains.,similarity:Contains 6 Kelch repeats.,tissue specificity:Expressed and secreted by activated T lymphocytes. Expressed at low to moderate levels in peripheral blood leuko
