基因名称(Gene Name)
CCBE1 KIAA1983 UNQ1921/PRO4395
蛋白名称
Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog)
免疫原
Synthesized peptide derived from human protein . at AA range: 120-200
特异性
CCBE1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010],
功能
function:Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.,similarity:Belongs to the CCBE1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 2 collagen-like domains.,tissue specificity:Not expressed in blood or lymphatic endothelial cells.,
