基因名称(Gene Name)
STAP2 BKS
蛋白名称
Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate)
免疫原
Synthesized peptide derived from part region of human protein
特异性
STAP2 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008],
功能
function:Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.,PTM:Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.,sequence caution:Alu insert from position 358 to 403.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with PTK6 and CSF1R.,tissue specificity:Widely expressed.,
