基因名称(Gene Name)
AEBP1 ACLP
蛋白名称
Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein)
免疫原
Synthesized peptide derived from part region of human protein. AA range: 780-810
特异性
AEBP1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013],
功能
caution:This protein has lost active site residues and zinc-binding sites and so is unlikely to be catalytically active.,function:May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor.,PTM:Phosphorylated by MAPK1 in vitro.,similarity:Belongs to the peptidase M14 family.,similarity:Contains 1 F5/8 type C domain.,subunit:Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By similarity). Binds to DNA in vitro.,tissue specificity:Expressed in osteoblast and visceral fat.,
