基因名称(Gene Name)
ZNF238 RP58 TAZ1 ZBTB18
蛋白名称
Zinc finger protein 238 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger and BTB domain-containing protein 18) (Zinc finger
免疫原
Synthesized peptide derived from part region of human protein
特异性
ZN238 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013],
功能
function:Sequence-specific DNA-binding protein with transcriptional repression activity. Binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core. May play a role in the organization of chromosomes in the nucleus.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 4 C2H2-type zinc fingers.,subcellular location:Associates with condensed chromatin.,subunit:Interacts with DNMT3A.,tissue specificity:Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.,
