背景
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008],
功能
domain:The transmembrane domain also contains the signal for ER targeting.,domain:The UBX domain is required for interaction with VCP.,function:Involved in endoplasmic reticulum-associated protein degradation (ERAD).,induction:By ER stress-inducing reagents, such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBX domain.,subcellular location:Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.,subunit:Directly interacts with VCP.,tissue specificity:Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).,
