基因名称(Gene Name)
UBQLN2 N4BP4 PLIC2 HRIHFB2157
蛋白名称
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
免疫原
Synthesized peptide derived from part region of human protein
特异性
UBQL2 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009],
功能
function:Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation.,induction:Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ubiquitin-like domain.,subcellular location:Where it colocalizes with the proteasome. Associated with fibers in mitotic cells.,subunit:Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit.,
