基因名称(Gene Name)
PURA PUR1
蛋白名称
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)
免疫原
Synthesized peptide derived from part region of human protein
特异性
PURA Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008],
功能
function:This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.,similarity:Belongs to the PUR DNA-binding protein family.,subunit:Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1.,
