基因名称(Gene Name)
OVOL2 ZNF339
蛋白名称
Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339)
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
OVOL2 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016],
功能
function:DNA-binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. Probably acts as a transcription regulator.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 4 C2H2-type zinc fingers.,
