基因名称(Gene Name)
TLX1 HOX11 TCL3
蛋白名称
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
免疫原
Synthesized peptide derived from part region of human protein
特异性
TLX1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010],
功能
disease:A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.,function:Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.,miscellaneous:TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.,similarity:Contains 1 homeobox DNA-binding domain.,
