蛋白名称
Synapsin-3 (Synapsin III)
免疫原
Synthesized peptide derived from part region of human protein. AA range 530-580
特异性
SYN3 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite directi
功能
function:May be involved in the regulation of neurotransmitter release and synaptogenesis.,miscellaneous:Regulated by calcium. Calcium inhibits ATP binding to the C-domain.,similarity:Belongs to the synapsin family.,subcellular location:Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.,subunit:Interacts with CAPON.,tissue specificity:Neuron specific. Detected predominantly in brain.,
