蛋白名称
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
免疫原
Synthesized peptide derived from part region of human protein
特异性
SPAG5 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008],
功能
function:Necessary for normal spindle formation during mitosis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed.,subunit:Homodimer, with a globular head domain and a long stalk. Homo-oligomer; the globular head domains associate, resulting in aster-like structures. Binds to microtubules in the mitotic spindle.,tissue specificity:Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.,
