基因名称(Gene Name)
FRZB FIZ FRE FRP FRZB1 SFRP3
蛋白名称
Secreted frizzled-related protein 3 (sFRP-3) (Frezzled) (Fritz) (Frizzled-related protein 1) (FrzB-1)
免疫原
Synthesized peptide derived from human protein . at AA range: 150-230
特异性
SFRP3 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010],
功能
disease:Defects in FRZB are associated with female-specific osteoarthritis (OA) susceptibility [MIM:165720]. It is the most prevalent form of arthritis and a common cause of disability.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.,tissue specificity:Expressed primarily in the cartilagenous cores of the long bone during embryonic and fetal development and in the ap
