基因名称(Gene Name)
ARHGEF15 KIAA0915
蛋白名称
Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)
免疫原
Synthesized peptide derived from human protein . at AA range: 560-640
特异性
ARHGF Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010],
功能
function:Specific GEF for RhoA activation and the regulation of vascular smooth muscle contractility.,PTM:Phosphorylated on tyrosine residues upon EFNA1 stimulation.,similarity:Contains 1 DH (DBL-homology) domain.,subunit:Interacts with EPHA4.,tissue specificity:Expressed in the vascular smooth muscle of coronary artery.,
