基因名称(Gene Name)
PRDM10 KIAA1231 PFM7 TRIS
蛋白名称
PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin)
免疫原
Synthesized peptide derived from human protein . at AA range: 280-360
特异性
PRD10 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
功能
domain:The SET domain is degenerated, suggesting that it has lost mehtyltransferase activity.,function:May be involved in transcriptional regulation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 SET domain.,similarity:Contains 10 C2H2-type zinc fingers.,
