基因名称(Gene Name)
PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235
蛋白名称
Plexin-A2 (Semaphorin receptor OCT)
免疫原
Synthesized peptide derived from human protein . at AA range: 600-680
特异性
PLXA2 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008],
功能
function:Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,similarity:Contains 4 IPT/TIG domains.,subunit:Interacts directly with NRP1 and NRP2.,tissue specificity:Detected in fetal brain.,
