基因名称(Gene Name)
ESCO1 EFO1 KIAA1911
蛋白名称
N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1)
免疫原
Synthesized peptide derived from human protein . at AA range: 10-90
特异性
ESCO1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
establishment of sister chromatid cohesion N-acetyltransferase 1(ESCO1) Homo sapiens ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008],
功能
caution:It is uncertain whether Met-1 or Met-2 is the initiator.,domain:The N-terminal region seems to be responsible for the association with chromosomes, thus excluding any involvement of the Zn finger in this process.,function:Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase.,PTM:Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the acetyltransferase family. GCN5 subfamily.,subcellular location:Nuclear at interphase, associated with chromosomes during mitosis.,tissue specificity:Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Hig
