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货号: YP-mAb-05564
促销价:

产品介绍

反应种属
Human;Mouse;Rat
应用范围
WB
抗体类型
单克隆抗体
基因名称(Gene Name)
TRIM63 IRF MURF1 RNF28 SMRZ
蛋白名称
E3 ubiquitin-protein ligase TRIM63 (EC 6.3.2.-) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (Striated muscle RING zinc finger protein)
分子量(DA)
38kD
免疫原
Synthesized peptide derived from part region of human protein
特异性
TRI63 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
来源
Monoclonal, Mouse,IgG
稀释比例
WB 1:500-2000
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
背景
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012],
功能
caution:It is uncertain whether Met-1 or Met-14 is the initiator.,developmental stage:Expressed throughout all developmental stages.,domain:The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.,function:E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.,pathway:Protein modification; protein ubiquitination.,sequence caution:Sequencing errors.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 COS domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Localizes to the M- and Z-lines in s

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