基因名称(Gene Name)
CAPN7 PALBH
蛋白名称
Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH)
免疫原
Synthesized peptide derived from part region of human protein
特异性
CAN7 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,tissue specificity:Ubiquitous.,
