蛋白名称
Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog)
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
AT7L3 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
domain:The SGF11-type zinc finger mediates the interaction with USP22 and ENY2.,function:Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.,similarity:Belongs to the SGF11 family.,similarity:Contains 1 SCA7 domain.,similarity:Contains 1 SGF11-type zinc finger.,subunit:Component of some SAGA transcription coactivator-HAT complex, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitinylation. Interacts directly with ENY2 and USP22.,
功能
domain:The SGF11-type zinc finger mediates the interaction with USP22 and ENY2.,function:Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.,similarity:Belongs to the SGF11 family.,similarity:Contains 1 SCA7 domain.,similarity:Contains 1 SGF11-type zinc finger.,subunit:Component of some SAGA transcription coactivator-HAT complex, at least composed of ATXN7,
