基因名称(Gene Name)
AGRN AGRIN
免疫原
Synthesized peptide derived from human protein . at AA range: 1900-1980
特异性
AGRIN Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015],
功能
function:Component of the basal lamina that causes the aggregation of acetylcholine receptors and acetylcholine-esterase on the surface of muscle fibers of the neuromuscular junction.,PTM:Contains heparan sulfate chains as well as N-linked and O-linked oligosaccharides.,similarity:Contains 1 NtA (N-terminal agrin) domain.,similarity:Contains 1 SEA domain.,similarity:Contains 2 laminin EGF-like domains.,similarity:Contains 3 laminin G-like domains.,similarity:Contains 4 EGF-like domains.,similarity:Contains 9 Kazal-like domains.,subcellular location:Synaptic basal lamina at the neuromuscular junction.,subunit:Binds to laminin.,
