基因名称(Gene Name)
RPL7A SURF-3 SURF3
蛋白名称
60S ribosomal protein L7a (PLA-X polypeptide) (Surfeit locus protein 3)
免疫原
Synthesized peptide derived from human protein . at AA range: 180-260
特异性
RL7A Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene t
功能
disease:Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.,similarity:Belongs to the ribosomal protein L7Ae family.,
