基因名称(Gene Name)
NFKBIL1 IKBL
蛋白名称
NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1)
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
IKBL1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009],
功能
disease:Mutations in the promoter region of NFKBIL1 represent the second rheumatoid arthritis susceptibility locus within the HLA region [MIM:180300].,function:May be a negative regulator of NF-kappa-B activation.,similarity:Contains 2 ANK repeats.,tissue specificity:Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.,
