蛋白名称
G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
GTSE1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008],
功能
developmental stage:Expressed in G2/M phase. Not detected in quiescent cells.,function:May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.,PTM:Phosphorylated in mitosis.,subcellular location:Associated with microtubules.,
