基因名称(Gene Name)
COL8A1 C3orf7
蛋白名称
Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin]
免疫原
Synthesized peptide derived from human protein . at AA range: 160-240
特异性
CO8A1 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011],
功能
function:Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells.,miscellaneous:Four consecutive Gly-Pro-Pro triplets are present at the C-terminus of the triple-helical region. These may provide the high thermal stability of this region.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Contains 1 C1q domain.,subunit:May form homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens.,
