蛋白名称
Epidermal growth factor receptor kinase substrate 8
免疫原
Synthesized peptide derived from human protein . at AA range: 130-210
特异性
EPS8 Monoclonal Antibody detects endogenous levels of protein.
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],
功能
domain:The SH3 domain mediates interaction with SHB.,function:Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.,PTM:Phosphorylated by several receptor tyrosine kinases.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer (By similarity). Interacts with BAIAP2. Interacts with SHB.,tissue specificity:Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.,
