储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
背景
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains,
which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to
bind free plasma hemoglobin, which allows degradative enzymes to gain access to the
hemoglobin, while at the same time preventing loss of iron through the kidneys and
protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its
regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also
been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1
diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis,
susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium
falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria.
A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript
variants encoding different isoforms have been found for this gene.
