背景
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial
antigen of prostate) family, and resides in the golgi apparatus. It functions as a
metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+),
using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe
involved in adipocyte development and metabolism, and may contribute to the normal
biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene.
