免疫原
The antiserum was produced against synthesized peptide derived from human Recoverin. AA range:107-156
特异性
Recoverin Monoclonal Antibody detects endogenous levels of Recoverin protein.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
其他名称
RCVRN; RCV1; Recoverin; Cancer-associated retinopathy protein; Protein CAR
背景
This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008],
功能
disease:Identified as the antigen in cancer-associated retinopathy, an autoimmune disease of the retina caused by a tumor in another tissue.,function:Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.,miscellaneous:Binds two calcium ions; one with high affinity, the other with low affinity.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,tissue specificity:Retina and pineal gland.,
